Is dementia hereditary? What causes dementia, and the risk factors

What the NHS says about genes and dementia, what causes the main types, the risk factors you can and cannot change, and how many cases could be prevented.

Last reviewed 3 min readBy Lift College Editorial

CPD guide

In most cases, no: the NHS says genes alone are not generally thought to cause dementia, although certain genetic factors are involved in some of the less common types. Dementia usually develops because of a combination of genetic and "environmental" factors, such as smoking and a lack of regular exercise. A family history of Alzheimer's disease is one of the things thought to increase the risk, and frontotemporal dementia is more likely to run in families than the more common types. The Lift College Dementia Awareness Training course covers what dementia is and how it affects people.

What causes dementia

The NHS says dementia is not a single disease. Different diseases cause it, and many are linked to an abnormal build-up of proteins in the brain that makes nerve cells work less well and die:

  • Alzheimer's disease: thought to be caused by a build-up of the proteins amyloid and tau
  • vascular dementia: reduced blood flow to the brain, for example after strokes
  • dementia with Lewy bodies: clumps of the protein alpha-synuclein
  • frontotemporal dementia: clumps of proteins, including tau, in the front and sides of the brain

Genes and family history, by type

  • Alzheimer's disease: the NHS lists a family history of the condition among the things thought to increase the risk, along with age, untreated depression and lifestyle factors linked to cardiovascular disease.
  • Frontotemporal dementia: the NHS says there is often a genetic link, and people with a family history may want to talk to their doctor about a referral to a geneticist.
  • Dementia with Lewy bodies: the NHS says it usually occurs in people with no family history, although there have been very rare cases that seem to run in families.

Risk factors you cannot change

The NHS names age (the older you are, the more likely dementia is, although it is not a natural part of ageing), genes, and possibly air pollution.

Risk factors you can change

The NHS says research suggests other risk factors, such as hearing loss and untreated depression, may also matter, and that a healthy lifestyle can help reduce the risk. Its advice includes eating a balanced diet, keeping a healthy weight, being physically active, drinking no more than 14 units of alcohol a week and stopping smoking. It says research concluded that around 4 in 10 cases of dementia could be prevented by changing the risk factors we can change.

Talk to a GP

If you are worried about your own memory or someone else's, the NHS says to see a GP, and to encourage the other person to make an appointment, perhaps going with them.

Training

Lift College Dementia Awareness Training is 1.5 hours in 5 modules, for care workers, healthcare, housing and customer facing roles, with a CPD Standards Office accredited certificate the same day you pass.

Frequently asked questions

Is dementia hereditary?
Usually not on its own. The NHS says genes alone are not generally thought to cause dementia, though genetic factors are involved in some less common types.
Is vascular dementia hereditary?
The NHS describes vascular dementia as caused by reduced blood flow to the brain, for example after strokes, rather than by genes. Its risk factors overlap with those for heart and circulation problems.
Is Alzheimer's genetic?
The NHS lists a family history of Alzheimer's disease as one of the things thought to increase the risk, alongside age and other factors.
What causes dementia?
Different diseases, often linked to a build-up of abnormal proteins in the brain or reduced blood flow to it. Alzheimer's disease is the most common cause.
Can dementia be prevented?
Not always, but the NHS says a healthy lifestyle can help reduce the risk, and research suggests around 4 in 10 cases could be prevented by changing modifiable risk factors.
Which type of dementia runs in families?
Frontotemporal dementia is more likely to run in families than the more common types, according to the NHS.

Sources checked

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